CONFORMATIONAL MASKING AND RECEPTOR-DEPENDENT UNMASKING OF HIGHLY CONSERVED ENV EPITOPES RECOGNIZED BY NON-NEUTRALIZING ANTIBODIES THAT MEDIATE POTENT ADCC AGAINST HIV-1

The mechanism of antibody-mediated protection is a major focus of HIV-1 vaccine development and a significant issue in the control of viremia.Virus neutralization, Fc-mediated effector function, or both, are major mechanisms of antibody-mediated protection against HIV-1, although other mechanisms, such as virus aggregation, are known.The interplay

Glucose consumption in many types of cancer cells, in particular hepatocellular carcinoma (HCC), was followed completely by over-expression of type II hexokinase (HKII).This evidence has been used in modern pharmacotherapy to discover therapeutic target against glycolysis in cancer cells.Bromopyruvate (BrPA) exhibits antagonist property against HKI

Abstract Background Named Entity Recognition (NER) is a long-standing fundamental problem in various research fields of Natural Language Processing (NLP) and has been practiced in many application scenarios.However, the application results of NER methods in Chinese electronic medical records (EMRs) are not satisfactory, mainly due to the following

Background: Preschool years are an important time for shaping healthy eating behaviors.Childcare centers can be a venue for policy change for broad and sustained positive impact on healthy eating environment.The objectives of this study were to assess how self-reported current practices align with updated statewide childcare center licensing regula

To reduce the pesticide load in industrial plantings, it is necessary to use pathogen-resistant varieties when establishing orchards.The problem of obtaining stable, large-fruited, adaptive varieties is acute, since there are practically no genotypes in NOR. GOLD SUPER CRITICAL OMEGA the existing assortment that combine a complex of economically va